Even after numerous earlier in the day studies reporting a link ranging from hypertension and you can the latest urinary Na + /K + proportion you will find some constraints as sensed
At present there is conflicting evidence regarding the potential blood pressure lowering effects of a reduction in urinary Na + /K + excretion. The TAIM randomized control trial in hypertensive participants on a pharmacological intervention reported no significant difference in DBP between the control diet group and a low Na + /high K + diet group during a six month period . A multicenter study by Suppa et al. conducted in hypertensive participants reported a significant reduction in SBP following 4 weeks of modified low sodium high potassium salt intake compared to participants receiving a normal salt intake , yet all participants were receiving a beta blocker, which is not standard first line treatment for hypertension . In addition, a cross-sectional study, the Dallas heart study, which reported an increase in SBP for an increase in the urinary Na + /K + ratio is limited by the modest correlation the use of single morning urine sample . The PURE study reported a strong linear association between estimated Na + /K + ratio and SBP, that was maintained after covariate adjustment, with the greatest SBP observed with the highest estimated K + and lowest estimated K + excretion . Although we observed that a daily K + excretion of <1 g/day is associated with elevated SBP we observed no association between the urinary Na + /K + excretion ratio and SBP at screening or following DASH-dietary intervention in SS or SR participants. In conjunction with the study by Zanetti et al. , our data suggest high Na + and low K + excretion may increase the likelihood of having increased SBP. However, the lack of association between urinary Na + /K + ratio and SBP in our data do not support a urinary Na + /K + molar excretion ratio of 1:1 as a mechanism to lower blood pressure [16, 17].
The present day data has several advantages: (1) The fresh Dashboard -Salt demo are a very carefully regulated eating investigation and conformity is continuously tracked, (2) The latest crossover framework having Na + input invited participant’s so you can serve as her control and you can reduced inter-people variability, (3) 24-h ambulatory blood pressure level tracks was pulled, (4) lack of the fresh confounding outcomes of antihypertensive mediations, and you may (5) 24-h pee attempt range. The top limitation of your expose study ’s the apparently modest sample dimensions which can has reduced all of our statistical power to select smaller ramifications of urinary Na + , K + , and you may Na + :K + ratio toward SBP. Even as we didn’t to see an imbalance within the baseline functions, recurring confounding inside our studies is possible.
After that, the new INTERSALT study, and that documented a confident association between the urinary Na + /K + ratio and you can blood pressure levels claimed a loss in analytical dependence on the latest relationship in 44 of your own 52 stores once improvement to own covariates as well as decades, gender and you will Bmi [32, 33]
To close out the present day data of your own Dash–Sodium Demonstration reveals that weightloss K + supplementation is not https://datingranking.net/pl/dominican-cupid-recenzja/ regarding the all the way down SBP and therefore the brand new reductions for the SBP noticed pursuing the Dash weight-loss intervention occurred independently off a good reduction of new urinary Na + /K + excretion proportion no matter new salt susceptibility away from blood pressure. Our research do not keep the facilities out of a-1:step 1 molar excretion proportion regarding Na + /K + while the blood pressure levels reducing means in the You Ebony and you can low-African Americans and hold the DRI recommendation to not recommend each day K + intake guidelines. Considering the constraints of most recent research together with ongoing debate regarding your part away from weight loss K + to the blood pressure coming very carefully managed research is required to clarify the potential perception regarding slimming down K + and you may urinary Na + /K + removal ratio towards the blood circulation pressure both in hypertensive and normotensive SS and you may SR users.